Hello @docme, Welcome to Connect. I'm glad to hear the prednisone is provide relief for your SFN symptoms. It's interesting that your idiopathic SFN is being treated with prednisone. I wasn't aware of prednisone being a treatment. I also have idiopathic small fiber peripheral neuropathy but only have some numbness and haven't found any medications that help with the numbness. I have taken prednisone for 2 separate occurrences of polymyalgia rheumatica (PMR) and started both at 20 mg. I'm glad to be off of it now but it definitely helped with the PMR pain. I was always concerned with long term use of prednisone even though it can be a necessity for some conditions. I did find some information on the topic that may be helpful to others looking for something other than the normal medications prescribed for neuropathic pain.

"Will prednisone help with neuropathy?
Chronic inflammatory demyelinating polyneuropathy responds to immunosuppressive treatments, such as prednisone, intravenous immunoglobulin, and Plex. Treatment with daily prednisone is inexpensive and effective but is associated with long-term adverse effects."
--- Treatment of Chronic Inflammatory Demyelinating Polyneuropathy With Pulsed Oral Steroids: https://jamanetwork.com/journals/jamaneurology/fullarticle/1107517.

How long have you been on the prednisone treatment?