After chemo, radiation and surgery, I think I had 6 months of Signatera tests that were zero showing no signs of cancer. Then the signatera tests became positive .03, .06, 1.1, 4.2 and up. Scans did not detect any cancer until the 4.2 reading. By the time we did the cryoablation, the Signatera result went to a 15. After the cryoablation I was put back on FOLFOX for 6 rounds. By the 3rd round my Signatera was back to zero. After these 6 rounds they dropped the chemo that causes neuropathy but continued with the other 2 chemo chemicals for another 12 rounds. I have done 4 of these with 8 more to go. The hope is that any residual cells that may try to pop up over a longer term will be killed off with these additional treatments and not become a problem and gone forever. I am on a 2 week Chemo schedule. I don't feel too good after treatments for 4 to 5 days and then start feeling better over that second week. Workwise I do what I can to help out but I am not as directly involved in day to day operations anymore. I have quite a bit of nausea and fatigue for the first week after chemo treatments. Constantly taking the nausea medication helps quite a bit. Hang in there and keep reaching out to people for all the info you can get.