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severe peripheral neuropathy and vitamin B6

Neuropathy | Last Active: Sep 6 5:25pm | Replies (46)

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@ray666

Good morning, @pain3relief, and welcome to Connect!

I, too, have peripheral neuropathy, or, after a year and a year of trying to arrive at a more precise diagnosis, I’m now able to say I have large fiber (predominantly sensory, with a dash of motor and autonomic) multifocal polyneuropathy—a mouthful, I know. Fortunately––and boy, do I mean fortunately!––I have no pain, none whatsoever; my symptom is twofold: wobbly balance and unsteadiness walking. Until my neuropathy, I’d not heard of the B6 “controversy.” Like so many of us, I was confused at first. In one place, I read: You must have an adequate amount of B6; in another, I’d read: Be careful because B^ can be toxic (mimicking neuropathy symptoms)! When my neurologist prescribed a “medicinal food” called EB-N5, telling me it would help keep my B6 load up to snuff, I became even more confused––and a bit alarmed (Why would my neurologist want me to take something with added B6 if B6 is toxic?) He was the one who first explained to me (also @johnbishop) that B6 comes in two distinct “flavors: pyridoxal phosphate, which is water soluble and non-toxic (what I’m getting in my EB-N5), and pyridoxine hydrochloride, which the body can over-accumulate and is toxic (the B6 we find in all of our favorite supplements). I used to take a host of supplements. I’ve since stopped taking supplements containing the potentially toxic B6 (pyridoxine hydrochloride) and sticking only to my EB-N5 with its non-toxic pyridoxal phosphate. The best news? I feel pretty good except for unsteady standing and my silly way of walking.

I wish you success as you learn more about your own neuropathy. And again, Welcome to Connect!

Cheers!
Ray (@ray666)

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Replies to "Good morning, @pain3relief, and welcome to Connect! I, too, have peripheral neuropathy, or, after a year..."

Thanks Ray for the Welcome and your information on B6.

I was diagnosed with severe peripheral neuropathy after years of numbing feet.

My symptoms seemed to worsen after a non explainable seizure. With numbness in my my feet increasing up my legs with terrible pain and what felt like shocks going through my toes.

I was told that nothing could be done but to handle with medication (pregabalin). The pain is getting better with slowly increasing the dosage. I still have poor balance and can’t walk without shoes.

The reason I was looking into B6 because I researched that B6 can increase/worsen symptoms of neuropathy

We had a case here in Australia, where a man was told by his doctor to increase his B6 intake and over time lost the ability to walk. Once the reason was discovered and intake reduced, his slowly started to improve.

I will keep researching and discuss further with my doctor and neurologist(which you only get to see every 3-6 months)

Thanks again, I’m glad I discovered this forum to better understand neuropathy.

@ray666 . Hi Ray. Just wondering if you are still taking the doctor prescribed vitamins you mentioned with the P5P b6. Really curious to know if this has helped the numbness etc. We have the same diagnosis and symptoms. Thanks for any info you have. Bonnie

Thank you so much for clearly explaining the difference between the two B6's.
So very helpful.
Grampa Lou