I took the Big 3 for 1 year and tested negative for MAC the entire 12 months. I also took inhaled Amikacin for 8 months and within that time it closed the 1.8 cavity I had. I really no side effects to speak of. NJH took me off of everything February 1st (Hallelujah) since I was doing so well. Now I pray to stay Negative for as long as possible.