After trying ALL the meds for anything arthritis related, prednisone remains the only thing that works. I was best on 12 mg methylprednisone but have been able to function on 8mg. Dropping to 4mg did not provide enough relief to work. Sadly, I know the side effects are bad for me but after almost two years of intensifying pain, I needed the relief and will stay with this until something better comes along. Good luck!