@proteusx Have you considered Repatha or Vascepa? The cardiologist put me on both of those as preventative. My cholesterol was controlled with the statin I was taking, but my HDL was never quite up to a desirable level. And my triglycerides were still on the high side. The Repatha lowered the LDL even further and increased the HDL to a good level. Then she added the Vascepa (Ethyl Icosapent) to help with the triglycerides, and it dropped them way down. I turn 73 this weekend, and like every other human I could be gone tomorrow, but it won't be for lack of trying to take the best care of my health that I can. I wish you success with the Niacin and I hope that it WILL have a positive effect on your PN. I've just read about the prescription Niastan that contains nicotinic acid. Something to bring up to my doctor when I next see him. Perhaps it would be more helpful than the Zetia. Do you experience any "flushing" from what you are taking! Best regards! Mike