Background: Age 66, Lipitor for 25 years (advised better to take small dose than not...for insurance). Also, Losartan, ADD, Clonazepam as needed, Testosterone, Estradiol, Finasteride, Minoxidil, and others, including OTC various supplements, pain relievers, PPI (Prilosec), Antacids, MTC Oil, Green Drink Supplements loaded with polyphenols etc. etc. including alcohol consumption (mostly wine, beer, tequila), one of them daily for last 10+ years (functional alcoholic). Had slight Osteoarthritis (autoimmune disease). not Diabetic according to tests.

Noticed Stage 2 CKD, monitored every 3 mos, watched while it got worse. Doc says OK. eGFR 59, 56, 54, 47!, 53.

Right foot began to tingle a few years ago. Was told by Podiatrist: not Morton's Neuroma, just a callous, shaved it down. no change. Year later: my PCP referred me to Neurologist. Said callous was just a wart(!) Did motor nerve conduction test...all OK, said it was PN. Prescribed Gabapentin (1200mg/day), sent me to Rheumatologist who prescribed Hydroxychloroquine 200 2 X/day, Meloxicam 25mg (strong NSAID). Meloxicam produced low kidney eGFR of 47. Yikes!

After going on Gabapentin for 10 mos, PN careened out of control to both legs, feet and hands. Freaked out. Dove into PN research (medical journals, YouTube, Neuropathy Specialists, anything "Neuropathy online . Engaged a Functional Doctor/Nutritionist. Blood test noted extreme inflammation. He prescribed extreme lifestyle and diet change to Paleo/Keto w/Intermittent Fasting with only Whole Foods (no preservatives... Difficult but have no choice). Eliminate Statins, Gabapentin, ADD meds, Clonazepam, OTC meds, continued supplements. Introduced a vitamin/herbal 3 month "cleanse", indicating it + diet changes was only way to see what's causing the inflammation, which is contributing to the NP.

Also Neurologist introduced electro-stim therapy to my legs & Feet 2
x per week - 24 sessions..

3 months into all of the changes above, I've lost 20 lbs, down to high school weight now. PN is localized mostly to bottom of feet (not hands, legs etc). Incremental improvement every week.

EXCEPT: Kidney still concerning - working with Nephrologist who said, stop all meds, OTC, and supplements that I can.

Now to your question: YES - I have skin itching (no rash, just needle pricks, and skin crawling, mostly in the evening and before bed. In the morning, all is fine (except numb tops and bottoms of feet.

Conclusion at this point: Alcohol triggered the PN. OTC meds contributed. High sugar, carb, chocolate diet, especially at night with alcohol, triggered onset of PN. Long term use of Prescription meds known to have PN as side effect laid the ground work for PN. Itching is most-likely caused by CKD as it is a known symptom. (Body not filtering properly, impurities (ureic acid, protein, etc) uses the skin "organ" in attempt to excrete impurities)

Apologies for long answer, but this autoimmune disease is very common, an can be caused be many things, The MD community will only treat symptoms. I've found it necessary to develop my own team and research, and use them all to move to a better state.

I will be introducing LLLT (Red light therapy) soon, due to positive scientific studies showing efficacy in controlling/reducing/eliminating PN.