I called Amgen today about the possibility of taking half dosage. She indicated it would be up to my doctor to approve the off label usage.. If I understood her correctly, weight was not a factor in the study for approval. I pointed out several times that full dosage for me would result in my receiving 5.7 mg/kg whereas the initial studies used 3 mg/kg dosages. I am sure FDA did not approve administration of almost 6 mg/kg.
I would gladly sacrifice some gain for safety.