Low dose Naltrexone didn't work for me. I was put on a 4.5mg and took it for a week, I had some negative side effects so I asked my compounding pharmacy to reduce the amount to 1mg. They got permission from my pain specialist and I began to take the 1mg. it had no effect wither positive or negative so I went off of it. I do know that a lot of doctor's are putting their chronic pain patients on this medication and I have heard it helps some people. For me, it just didn't work.