thanks I can honestly say that I am coming up on two years of lupron,,casodex Have had 30 visits of radiation . I tried one of the new powerful adt called apalutimide ,,,,, still cant spell it ,. I had a lot of problems with it, it felt like I was losing my mind ..Lost all ability regarding mental confusion and ability to conceptualize. So had to come off that .I am aware of the blood brain barrier and that was what my doc say to stay away from. The next decision is to give lupron a third year. Things are still undetectable . I am listening to every one here .At 77 I am doing daily gym workouts , they do help to take my mind off of side effects , esp the weight issue , Over all I am not going to torpedo any thing that keeps working. even if it does have some bummer side effects . And honestly at 74 the diagnosis was very surprising to say the least, I was not paying attention. Had full blown BPH , quite extensive and the PC mixed up with made up the perfect storm . . Any one have any comments about anything I would be glad to hear .