Hi Steve, Thought I would pop in while you wait for Ray @ray666 to respond. I do fit the metabolic syndrome and only learned of it a year or so ago. I had already started working on changing my lifestyle with losing weight, exercising more, eliminating as much processed food and sugar as possible and just being more conscious of healthier choices. I hadn't seen that research article but did run across quite a few others. I thought I would share them for others who aren't aware of the metabolic syndrome and it's connection to neurological disorders.

-- Diagnosis and Management of the Metabolic Syndrome
https://www.ahajournals.org/doi/10.1161/circulationaha.105.169404
-- The metabolic syndrome – What is it and how should it be managed?
https://journals.sagepub.com/doi/full/10.1177/2047487319886404
-- A comprehensive definition for metabolic syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675814/
-- The Metabolic Syndrome and Neuropathy: Therapeutic Challenges and Opportunities: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881591/
-- Metabolic syndrome as a risk factor for neurological disorders
https://pubmed.ncbi.nlm.nih.gov/21997383/

And the YouTube video that got me thinking more seriously about my lifestyle choices...
https://youtu.be/jIegMp5cWBY?feature=shared

Hi, Steve (@stallen)

I should have heard of metabolic syndrome before (and I probably had, but like so many things, it must have just zipped by). You and John (@johnbishop) have given me lots to read up on. Tomorrow, my weekly no-Internet day, I was planning on starting Zadie Smith's new novel, but now it looks like I'll be reading up on metabolic syndrome. 🙂

To answer your questions, Steve, my PCP found my blood pressure to be on the "high side," but not alarmingly so, and that diagnosis was 20-30 years ago; I have been taking a script medication for blood pressure ever since, but most days now the cuff tells me I'm a textbook "norm" (120/80). To the best of my knowledge, my cholesterol is fine (I can't recall my PCP ever saying it's not); I'm 99% off of all refined sugars (I quit cold turkey in 1976 when I read William Dufty's "Sugar Blues"); and my waist is "about right" (in my opinion): a little bulgier than it was in my running days, but nothing that would put a strain on my car's seatbelt (I'm 6'0" and weight 160-164 lbs.).

I'm not discounting the possibility (the jury's out until I read all the studies you've sent), but it doesn't sound like a good candidate for metabolic syndrome right now.

Ray (@ray666)

I'm not Ray but I have the idiopathic neuropathy with large fiber damage showing on EMG and nerve conduction but no pain and so far my activity is not greatly affected even though i am 70.. I don't have high BP Large waist or blood sugar issues. My BP RUN 120/80 pretty much always. Weigh 120 and physically very active. I started getting foot neuropathy about 10 years ago that progressed slowly. The only thing that showed up in all the test was b6 at a level 5 times upper limit. This was caused by melatonin which had added b6 and Emergc whichbi took for about 3 years until thevtest was run. The neuropathy continued to progress even after getting my b6 to normal but seems to have stabilized to just my feet and ankles. B6 toxicity is known to cause neuropathy and I don't know if the damage is permanent or not. Hope you find answers