My doctor and I talked about eventual lumpectomy. She indicated it was my decision, but she has to admit she like to see me extend my time on anastrozole since I made such tremendous progress the first 3 months. Lumpectomy is definitely in the future. Even though she can't find it in my left breast without a small clip being associated with it that they inserted for location purposes. She doesn't rule out lumpectomy, but the advantages of shrinking it so small means easier surgery, more of the breast is saved, and perhaps a happier outcome. The key thing that struck me and all the things that I've read is the fact that it has a 50 hour half life. Because it holds in your body for that long after you stop taking it means every other day is very feasible to me. But then it is not in my lymph nodes, and it's staying put. It has not metastasized . Every person is different. Good luck on your journey. As things change I will be posting them on this site. Thanks.