My husband is 74 years old. He has gone through many treatments that eventually stopped working. He remained on Lupron injections every 3 months consistently. He was first on dexamethasone 2 and 1/2 years, zytiga for 3 years, These were the more stable years and lower PSA levels. He had testosterone injections for a year that brought his PSA down and then stopped working. Re-tried zytiga last year but it failed. Because of the Pluvicto not being approved in the US until 2021 he waited without any treatment for 9 months. Then to have Medicare approval to try Pluvicto he had to go on chemotherapy drugs. He lost extensive weight and became very weak. This may have been the reason that when he was approved for Pluvicto he was in a weakened state and never really seemed to benefit from this treatment. I think it is going to be a life saver for many men.