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You might want to discuss this research with your doctor.
"Gigante et al. (Gigante et al., 2015) studied the effect of vitamin K2-7 (with and without vitamin D3) on differentiation of human mesenchymal stem cells (hMSCs) obtained from bone marrow. Vitamin K2-7 enhances the process of gene induction of osteocalcin that is initially influenced by vitamin D3. It was observed that vitamin K2-7 has an effect on genes involved in cell growth and cell differentiation which included growth differentiation factor-10 (GDF10) and insulin-like growth factor 1 (IGF1). In addition, co-supplementation of vitamin K2-7 influenced vascular endothelial growth factors (VEGFA) induction along with its receptor fms-related tyrosine kinase 1 (FLT1); FLT1 plays a role in both angiogenic and osteogenic processes. Co-supplementation of vitamins aided in bone-healing process by modulating the expression of genes involved in both mineralization and angiogenesis. Considering genes involved in bone formation and mineralization, vitamin K2-7 enhanced vitamin D3 gene induction of osteocalcin. Hence, co-supplementation strategy has the potential to help in better development of bone and reduce bone-related disorders."
--- Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237441/
Replies to "You might want to discuss this research with your doctor. "Gigante et al. (Gigante et al.,..."
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From my pcp: There are studies that show vitamin K helps vitamin D and calcium be deposited in bone rather than soft tissue. However, the only reason to take a vitamin is if your body is deficient in it. Vitamin K deficiency is very rare. So, except for rare cases where a person is deficient in vitamin K, there is no reason to take extra vitamin K. There is no benefit in having excess vitamin K.
The first sign of Vitamin K deficiency is significant bleeding that won't stop because it is needed to make blood clot. So, you most likely do not need to take vitamin K with vitamin D. From second dr: The claims of elevated cardiovascular risk with calcium and vitamin D supplementation are still in the controversial stage, and the claims that adding K2 helps reduce the risk are also (I believe) not well supported. I would like to defer the request for checking a vitamin K level to your primary care physician, because I am not sure how to interpret the results, and I am not sure of the medical necessity of such a test. I think (first dr) is more qualified to address this.