I think you make a good point. Are they looking at an original dosage or are they looking at a buildup of a dosage. When I told my breast center surgeon and reminded her of the 50 hours of half life she seemed to pause. I feel certain that the research is always based on long-term use, like a control group going on it for one year or something like that. Very curious. Right now I am sticking with every other day which has only been about 4 days now. I just want my symptoms to be lessened.