I’m also considering the effects of how long tamoxifen stays in my system, because it’s half life is 5-7 DAYS. By day 7, I have a full dose plus partial doses from the previous 6 days.
However, when the research is done they are looking at people who have accumulated that amount of drug in their bodies. Maybe it takes a whole lot of the drug to make a difference.
For example, if I’m on 5 mg tamoxifen then by day 7 I may have almost 9 mg of drug in my body. But that is what research is based on, so maybe it takes 9 mg to be effective. Does that make sense? Never sure if my explanations are clear.
For you if you’re taking 1 mg of an AI that has a half life of 50 hours, then 4 days after the initial dose you might have close to 2 mg in your body. But maybe 2 mg is what it takes to make a difference - and they prescribe 1 mg knowing that the effective level will end of being 2 mg.
That’s when I start questioning myself on whether I have enough information to self prescribe. I guess I like scary situations, because I do it anyway. Hopefully I won’t be proven so dumb that I made the wrong choice. In retrospect this might be one of those situations where I knew better but chose risky behavior (will I never grow up?!)