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← Return to Stopping Evenity Early
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Osteoporosis & Bone Health | Last Active: Jul 2 11:27am | Replies (115)
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This is from the Japanese Study where the dosage was varied.
"For the primary efficacy endpoint, each dose of romosozumab increased BMD at the lumbar spine significantly compared with placebo at month 12 (Fig. 2 and Supplemental Table S1). The mean percentage increase from baseline was 0.9% in the placebo group and 8.4%, 13.3%, and 16.9% in the romosozumab 70, 140, and 210 mg"
Factor in our smaller weight and the effectiveness of a 105 mg dosage might be approaching being equivalent to a full dose for a 150 lb woman.
Replies to "This is from the Japanese Study where the dosage was varied. "For the primary efficacy endpoint,..."
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I went in for my second Evenity today and declined the second shot. The nurse said they have people stop early at 6 months, but not sooner.
Here is what I wrote elsewhere about today and my decision:
I had met with an allergist at the request of my endo. Allergist said I should pause between shots to ascertain effect before having second one. Nurse said I could only have a one minute pause. I got her to wait three. I decided against the second injection. Thigh injections are absorbed more slowly that tummy. By the time I got to my car, same burning band of tightness in mid abdomen, but more tolerable than two injections last month (which had an intense effect w/in a minute).
I read initial studies that based dose on weight. Standard dose is 3mg/kg for someone 150 lbs. I weigh 104. Essentially 3mg/kg would be about 140mg Evenity. One shot is 105mg, two shots is 210mg. Basically I got 2m/kg with one shot versus standard 3. That was reported as 1/3 less effective but still pretty good. Basically 10% increase vs 16% (see post above by @normahorn).