@lightandhope ,

Your partner should definitely seek out a genetic counselor and have a "germline" DNA test for inherited mutations. There are several (known) mutations associated with a higher chance of developing pancreatic cancer and possibly more unknown, but a family history like that is reason for concern.

FWIW, my paternal grandfather had a digestive cancer (not sure which organ), and my paternal grandmother had breast cancer. We didn't know anything about their genetic status, but we do know my dad (RIP, mesothelioma), a sibling, and I all have mutated versions of the ATM gene, which is a risk factor for breast and digestive cancers. I have pancreatic cancer and my sibling is closely monitoring a pancreatic cyst.

There are some fairly standardized screening guidelines (a few searchable in this forum), based on patient age, number of immediate relatives with cancers, the age at which the relatives were diagnosed, and genetic mutation status (which you'll know after a test). These categorize a patient as normal, elevated, or high risk, and good doctors will take a patient with this information and happily start the appropriate screening process.

Update: There are several searchable discussions for the keyword "Fukuoka" Guidelines related to screening and monitoring pancreatic cysts, and also to MD Anderson's recommendations for PC screening. Link to that one is here: https://connect.mayoclinic.org/discussion/monitoring-a-pancreatic-cyst/?pg=3#comment-990548