Thanks for your kind and thorough review.

Defining natural, supplement, and phytochem.

Natural [my definition] is anything received from a plant or plant part. All my natural supplements are either 1) age tested (the item has been used hundreds of years and is written about in culture and history books), 2) published research as you stated [not in US or western because our whole system is based on the pharmaceutical testing and supply line] [sidebar, the approved medicines are only tested on very small cohort, as a whole in multiple test beds - and if emergency status given some of these are subverted - example Covid vaccines - populations and when the product is approved then the whole population of users...examples of serious adverse events: Celebrex, Metformin, some vaccines - older, etc.

So, FDA is far from perfect and the process is far from "fool proof" because the pipeline has to turn out products in a reasonable time, with proper testing, and approval or pharma will not invest]. Back to list: 3) what I have personally tested on myself, recorded dosage and response over time and have seen other close relationships use without any side effects (as much as 50 to 100 plus people depending on the item examined).

Supplement is ONLY a plant extracted or simulated same extract product. The tests of 1 through 3 apply here also.

For natural, supplement, or plant extract:
I am not suggesting anything which is harmful. Each item discusses is reviewed for potential interactions listed on vetted websites. All items listed I find are always noted in discussion.

Example: tumeric (curcumin) reacts with Apixobam (Eloquis). Unknown frequency and unknown reaction. This is weird and not normal having no side effect listed. Apparently something has been seen and reported, but is possibly ambiguous as to determining what is really the side effect. This is my guess on this.

Point: anything suggested is a) published information in refereed journals, b) interactions are reviewed, c) tested on myself and sufficient number of other close aquintenances, d) is a very long standing historical or cultural "method or natural - plant remedy".

It is worth mentioning, prior to the later 1980s with significant technological increases in synthsizing medications that could be tested on rabbits (for decades) and now mice or rats (people do not complain about testing on these) that skightly less than 50% of our pharmaceutical products (medecinea) came from plants, bacteria, or fungi. Willow bark is high in salacylic acid. This is how asparin was developed.

The statements I write can be searched on the internet to find a plethera of supporting information.

My Ph.D. is in pathology and microbiology. The emphasis was plant and host plant resistance. My Masters is in Biology. My bachelors is in plant and soil science focus on chemistry and physiology.

Many techniques used in the human or animal sectors were developed in plants, vetted, then adjusted for animals and humans. Example: gene gun, bacterial, and viral genetic vector used for modification of DNA or RNA, most of marker assisted selection, etc.

How where the methods copied? The same companies that are pharmecuetical makers own (used to be the same) subsidiaries in these fields animal health, plant health, seed, or neutraceutical industries.

Examples:
Ciba
Astra Zeneca
Heorst Rochelle
Bayer
Rhome Palank
And the list is as long as your arm.

Methods were developed in plants and tranferred to humans. Certainly not all, but most since the tech and sythesis revolutions related to DNA and RNA occured. Research may have been on humans originally (this is where the funding is large) in various cases, but the test bed of method and method development was in plants.

Example: in dicot plants a non symptomatic virus is used to insert DNA or RNA into plants for genetic transformation. That is how all the Covid, more or less, vaccines and boosters were developed accept one. In plants, what we have seen with this technique is the remaining inserted virus continues to transfer to non intended hosts. This has occured with the vaccines for Covid also. Published research. Check OBGYN related.

Jt