So I have never been able to spit either - doctors had me go for induced sputums all the time. Nada! I did not have symptoms at the beginning either except I just didn’t feel well and couldn’t put my finger on it but was losing weight and I’m not a big person so that was concerning. The Big 3 never agreed with me no matter how many times I was on them, but Arikayce was easy for me in terms of outward side effects. It is time consuming because you have to sterilize equipment each time. I was in a clinical trial so had to keep a journal etc. etc.. The visible side effects I had were coughing during and after use. The only way for doctors to find out if it was gone was with a bronchoscopy. I have had many over the years. I also have CT scans every 6 months now. Arikayce did kill the MAC. Irene5