Starting chemo for ovarian cancer for the second time.

I had 3 rounds of chemo prior to having a total abdominal hysterectomy, breezed through it. Had 3 more rounds after surgery…..felt horrible! Like you, could barely make it to the bathroom, barely took a 1 minute shower due to shakiness & weakness, no appetite. After speaking with my oncology RN, she told me that side effects tend to get worse the more have. Thanks for telling me that upfront, I was about to go to the er!! Lasted almost a week. Had CT scans in Dec, all clear & doctor said I didn’t need maintenance. Recently repeated CA125 & it jumped to 162 so he ordered a pet scan scheduled for 1/31. I’m a wreck!!! Prayers to all dealing with this horrible beast! 🙏

I just had my second infusion today, and it was a disaster. The Keytruda and paclitaxel were fine, but I had a fairly severe reaction to the carboplatin. I've been hanging out in the ER ever since then, while they're waiting to see if the allergic reaction will start up again when the drugs wear off. Since I've been sitting here, I've been reading up on carboplatin sensitivity reactions. Apparently they're most common in exactly my situation: the second infusion after you re-start carboplatin after a long break.

I wondered if you're having a less severe version of the same thing.

Hello @val64! I have been thinking about you a lot and wondering how you are doing? I know you had an awful experience with your chemo treatment and ended up in the ER. Just wondering if you've had another treatment and how it went! Hope it helps to know people are thinking about you!

Thanks so much for thinking of me. It does help me feel less alone.

My third round of chemo, using the carboplatin desensitization protocol went fine. Instead of infusing it in 30 min, they took 5 hours. So after the blood tests, pre-medication and 3 hours of paclitaxel, I was there almost 12 hr. But no problems, so I'm grateful that I can keep taking it.

Thanks so much for thinking of me. It does help me feel less alone.

My third round of chemo, using the carboplatin desensitization protocol went fine. Instead of infusing it in 30 min, they took 5 hours. So after the blood tests, pre-medication and 3 hours of paclitaxel, I was there almost 12 hr. But no problems, so I'm grateful that I can keep taking it.

Please try to relax, CA125 can rise when your not feeling well too. My Dr. told me of a patient who had high ca125, and next couple days, proved positive for a virus. A month later the numbers were back down. It’s so not fare, the anxiety can make you sick enough in itself. I usually try to walk it off, they kind of screwed me there with the neuropathy, I’ll do what i can when I can. I feel for you. My first checkup is coming soon, not sure of maintenance drug if any. No mutations that i know of so far.
A part of me just wants to stay ignorant and carry on with where i am. Hang in there, hope it’s just a bug or virus, hugs

Thanks for your input. Had a pet scan, showed a small area behind my intestine. Starting Doxil & Avastin 2/6, have an echo Doppler 2/2 before starting Doxil. I’m terrified of the side effects! Praying hard it zaps this beast!