Lyumjev vs. Humalog

I’m not familiar with it, but hope you get some input here. I am type I, on pump and use Novolog. I get how faster acting would be appealing. If my BG spikes, it seems like 30 minutes is a long time to start working,

It sounds like it might be a good switch and definitely worth discussing with your doctor.

--- Ultra rapid lispro (Lyumjev®) shortens time to recovery from hyperglycaemia compared to Humalog® in individuals with type 1 diabetes on continuous subcutaneous insulin infusion:
https://pubmed.ncbi.nlm.nih.gov/37814517/
--- Lyumjev insulin: Dosage, side effects, uses, cost, and more: https://www.medicalnewstoday.com/articles/drugs-lyumjev

@celia what kind of pump do you have? I have an Omnipod 5 pump and it uses Humalog.

@cehunt57 ,
I have a new Medtronic 780 with G4 cgm still in the box that I’m preparing to use. I have a few more classes to take yet, but I’m wearing a Medtronic 670 with G3 cgm that I’ve been using for last 5 years.

@celia16 so your CGM and insulin pump are both Medtronic products. You are sticking with Medtronic but upgrading. The Medtronic pumps use Novolog? Could you keep us posted on how you are doing with the upgrades as you adjust? I’m really curious about the other technologies.

@cehunt57, Yes, I’ve upgraded and am anxious to start using the new model, but there are classes I need to complete, plus there is a week to 2 week period that you initially won’t be in auto mode. I am anxious about that, as I stay in auto mode almost all the time. It really helps me. I plan to put getting set up on it as a priority and will post how it goes.

There are a lot of opinions about the various pump and cgm brands. I decided to go with the 780 after doing a lot of research and reading others’ experiences within the diabetes online global community.

@cehunt57
How do you like the Omnipod and do you use a cgm?

Isn’t anybody using Lyumjev or Humalog Kwikpen?

@celia16 I have a Dexcom G6 continual glucose monitor (CGM) as of February 2022. I have experienced some inaccuracies with that, particularly in the 24 - 72 hours after a sensor change. For example a greater than 100 point difference between CGM reading and glucometer reading. I know all about that CGM tests interstitial fluid and glucometer tests blood sugar. But still it was frustrating (especially in regards to low alerts) when CGM warned me that I was less than 40 and glucometer showed 139! Before checking the glucometer I panicked, overtreated and spiked to 300+. Lesson learned. In the 24 - 72 hours after a sensor change I check the glucometer often.

For the insulin pump I use Omnipod 5 since February 2023. This was recommended for me by one of the Mayo Clinic (Rochester, MN) endocrinologists. My local endocrinologist was leaning towards a Tandem pump. Because of a Medicare eligibility requirement I found out that I was not eligible for coverage for the Tandem but I was for the Omnipod 5 under part D. So we went with Omnipod 5.
There turned out to be 2 benefits to that. At the time it was the only one that was tubeless (a small benefit). The more important benefit is that it communicates with Dexcom G6 in a closed loop to recommend mealtime and correction boluses using an algorithm based on calculated “insulin on board”. This has started to be way over my head mathematically speaking but I can’t argue with the results. My A1C is “good” according to my providers and the CGM graph is increasingly approaching a greater percentage of steady flat line time in range. Before it looked like a mountain range with terrible peaks and valleys.

Another thing I might add is that I had a Medtronic insulin pump prior to 2000. It helped me achieve an A1C less than double digits but it was “ver primitive” according to my husband. I felt it was not user friendly at all. That was a long time ago. I hope your experience with Medtronics pump is better.

Could you keep me posted on how it’s going?

@cehunt57 ,
I appreciate that perspective. I actually used Dexcom before I got my pump. I found that it gave me wildly off numbers at that time. I eventually discovered that it was much more accurate if I wore the sensor on my upper arm and not my belly. (I don’t know what the current recommendation is. )After I got my Medtronic, I wore the Dexcom and Medtronic at the same time, different arms for a couple of weeks, since I had some extra sensors. I found them to be very close. Basically the same.

I look forward to using my 780. Some of my online buddies report 90% and up time in range! The micro boluses are supposed to bring you down, even if you forget to bolus. Plus, I look forward to not calibrating.

It sounds like you have done very well. If you find something that works, that’s what counts. It feels so nice to have well managed blood sugar. I’m considered good control, but want great. I’ll probably start a thread after I know more.