While "The Protocol" supplement formulation that you discuss has some ingredients that may be beneficial in some forms of neuropathy in some people, I object to the way it is marketed and consider it unscientific and something of a rip off. At the Protocol website its creator has a list of questions and answers, one of which asks if an ingredient can be eliminated. And the answer provided is: "In a word, NO. The Protocol IS." The Oracle has spoken and has, in effect, declared that this particular formulation has been irrefutably validated and simply now IS fact, not to be questioned. The truth is there is no such validation, not even a single credible study to support this formulation. I also strongly object to the creator of this product advising sufferers of peripheral neuropathy to ignore the advice of medical doctors who run tests and find that levels of certain micronutrients are too high; as the medical advice in question here went contrary to the absolute Protocol, the manufacturer of it advised the patient to consult a naturopath or other non-M.D. medical adviser. Do that at your own peril. Finally, you can do far better simply buying individual supplements rather than spend the roughly $180 per month for this highly questionable product, which, additionally, lacks any credible third party testing for truth in labeling, impurities, etc. I strongly advise all who use supplements of any kind to check with a reliable third-party tester of products, such as ConsumerLab before buying ANY nutritional supplement. Some of them can be highly hazardous to your health, and others are grossly mislabeled and fraudulent.