@carlosmayo So many variables. In addition to Naltrexone, Mayo prescribed Cymbalta (which per their direction I have discontinued). I have continued to take many supplements, practice vagus nerve exercises, forced daily breaks, moderation of activity, zero alcohol, and constrained exercise. So, which is it out of all of those, one thing, some things, all the things. Will never know. Very happy to be off the Cymbalta, towards the end it made me feel incredibly unmotivated and lazy. Once off that I had a bounce to the good. I also had a bounce to the good after my last case of COVID. And then there's that darn variable again, time . . .