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How Long For Body To "Reset"?

Osteoporosis & Bone Health | Last Active: Feb 10 3:24pm | Replies (36)

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@gently

Good thinking. I wish you had an endocrinologist who would order serum CTx.

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Replies to "Good thinking. I wish you had an endocrinologist who would order serum CTx."

In your response to surefire, you suggested the possibility of taking a lower dose to guard against adverse side effects. I think that's a very good idea worth exploring with my doctor. Given that I had taken relatively few (3) doses of Prolia before stopping, perhaps I do not need to take the full dose of Reclast/ Zometa to mitigate the rebound effect.

In fact, your suggestion led me to do some digging and I came across an article which suggests that, in the case of zoledronate, a lower dosage may actually be beneficial. Unfortunately, I am not able to post a link yet, being a new member but the following is a quote:

"Zoledronate has been in clinical use since 2007, and evidence suggesting that less treatment with zoledronate than 5 mg annually might effectively reduce fracture risk has been available for almost as long [Grey et al. 2009]. "

Another thing I have been wondering is, whether the doses of Alendronate that I have taken since stopping Prolia can be taken into account to reduce the dosage of Reclast/ Zometa for the purpose of mitigating the rebound. For eg if I do 6 months Alendronate, can I just do 6-month (half) dose of zoledronate? In other words, would "6 months of Alendronate + 6-months' dose of Reclast" work as well as "12 months of Alendronate"?