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How Long For Body To "Reset"?

Osteoporosis & Bone Health | Last Active: Feb 10 3:24pm | Replies (36)
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@gently

Reclast is the recommended bisphosphonate following Prolia. It will remain in the bones and blunt the effect of the anabolics, but not completely. The latest I've read is 1 1/2 to 2 years. With the caution that more study is needed. It seems to me that combination therapy following Prolia would be more protective, maybe zolendronate and abloparatide. I haven't found any research yet.
Luckily you haven't been on Prolia for a very long time. And you've made a good decision.
You might consider finding an (other) endocrinologist.
It is surprising to me that anyone is prescribed Prolia. If you aren't cautioned about the drug, is that because the prescribing physician just doesn't know. Or, is there is something I don't know.
Bone markers could be helpful.
Thank you for your prayers.

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Replies to "Reclast is the recommended bisphosphonate following Prolia. It will remain in the bones and blunt the..."
surefire | @surefire | Jan 26 8:23pm

Yes, Reclast is often recommended as the relay drug following Prolia. And i believe Dr McCormick is of the opinion that once you have taken 3 or more shots of Prolia, Reclast would be required as Alendronate would not be potent enough to mitigate the rebound effect

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formisc | @formisc | Jan 26 11:48pm

I am terrified at the thought of putting in a year's dose of drug into my body through infusion. Also, for Reclast to be effective as a relay drug, the correct timing would have to be determined with the help of bone turnover markers which my doctor is not willing or unable to order. For these reasons, i decided on Alendronate instead. If it's true that Reclast stays in the body for only 2 years, that's a huge plus. I have read that Alendronate can remain for years, even decades after

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06111945cc | @06111945cc | Jan 27 8:49am

How does this fit in?

“ Combined treatment with teriparatide 40 μg and denosumab increases spine and hip BMD more than standard combination therapy. This large and rapid increase in bone mass suggest that this high dose regimen might provide a method of restoring skeletal integrity in patients with osteoporosis."

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