Well, not yet. I am going in for a colonoscopy next week to confirm the disease is active again. When I told the doctor about my medication history he didn't seem to be particularly concerned even though I had been unsuccessful with both conventional and biologic treatments previously. I really don't want to repeat these meds because they were either ineffective or had bad side effects. So I am limited. This is why I am so anxious to hear about other treatment options. Thank you!