Yes, I asked the CRNA at our pain clinic for it last summer, his first patient to use it. On 4.5 mg now for the next few months. I can't tell is it's helping as I flare regularly trying to taper.

Hello @cgm. I combined your discussion with an existing discussion titled "Low Does Naltrexone and Prednisone" - https://connect.mayoclinic.org/discussion/ldn-and-prednisone.

I did this so you can meet the many members who have been prescribed low dose naltrexone, like @sandmason, @emo, and @janielou56 have shared their LDN experiences.

@cgm, if you are comfortable sharing, has this treatment regimen been prescribed for you? Have you tried other treatments in the past?

I’ve been taking it for three month but not noticed any difference. I was so hopeful…..

Hi there- I am a caregiver for my father who has PMR. He’s been taking LDN 4.75mg (it’s an unusual dose, I know) for over a year. I also take it, but I have a different inflammatory arthritis.

In both our cases, it does more for fatigue. It’s hard to tell the effect on inflammation, though my current rheumatologist does prescribe it to her patients who are interested.

In my father’s case, he still gets flares with tapering—I feel the flares are more a result of the speed of the taper, than influenced by things that could be done to prevent it. But for what it’s worth, his flares have been less severe—whether it’s due to the LDN or our adaptations to adjust the taper, it’s hard to know. We do feel it improves fatigue for us though.

I think it’s worth a try if you’re willing and also can stomach the price. Side effects and risks are very low (and I’m very leery of side effects and struggle to tolerate many medications). We use CareFirst Specialty Pharmacy in New Jersey, and they have the best rates we’ve come across.