I had a horrible reaction to Letrozole. I had neuropathy from chemo that was minor and fading fast. Letrozole immediately made the neuropathy far worse than it had been, as well as sucking the energy and happiness -- finally recovered post-chemo -- out of me. I'm not sure estrogen suppressors are worth it because I want to be happy and feel good during the time I have left on Earth, however long that might be (I turn 64 at the end of February). I went through a lumpectomy, chemo, and radiation; the latter 2 were purely prophylactic, as the margins on my Stage 1A Invasive Ductal Carcinoma were clear and it had not spread to the sentinel lymph node. Osteoporosis and unhappiness from estrogen suppressors may be a bridge too far for me. I'm switching to Exemestane as soon as the neuropathy clears up, as my sister, who had DCIS 8 years ago, tolerates it. But I'm tired of treatments that make me feel terrible. I thought I was getting to the light at the end of the misery tunnel when the therapeutic cell destruction was over: Cutting, poisoning, and cooking. But I reckon the medical community has determined that's not enough torture for a woman with breast cancer.