I have been taking Guanfacine (2mg, extended release, at bedtime) for over a year now, and for me it has made a *huge* difference in the cognitive issues (brain fog, lethargy, etc). I took my first dose on Christmas Eve 2022, and I woke up to the best Christmas present ever -- for the first time in more than two years I actually wanted to get out of bed and engage in the day. Prior to that I would take 70mg Vyvanse when I woke up, and then sit in bed waiting for it to kick in so I could drag myself out of bed. I have since decreased the Vyvanse to 40mg and still want to get out of bed (well, at least most mornings).