← Return to Has anyone taking Tamoxifen experienced heartburn with abdominal pain?

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@lyleswan

I am sorry you've experienced these side effects. I had IDC and surgery in 2022. With 10 mg of tamoxifen I experienced extreme exhaustion and digestive issues which included abdominal cramps, nausea, loose stools. I also had intense brain fog and could not function. These symptoms lasted all day. My oncologist would not consider prescribing 5 mg. I cannot take AI's due to severe osteoporosis. I stopped tamoxifen after a few weeks and am not taking any anti-hormone medication.
I do take omeprazole and Pepcid for major reflux/gastritis caused by Herceptin. My GI says it is fine to take antacids while on the other meds I take. Omeprazole is the only med which controls my acid reflux/Gerd.
I hope this might be somewhat helpful for you and I really hope your symptoms lessen. All the best.

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Replies to "I am sorry you've experienced these side effects. I had IDC and surgery in 2022. With..."

Guidelines changed at MD Anderson in 2022 and they came out with an update on care, including tamoxifen, later that year. When I saw the survivorship provider at MDA in April 2022 the guidelines were still for 20 mg, later in the year they added 5 mg as an option for those who could not tolerate 20 mg. MD Anderson has nomograms they have developed that guide practice. They are available to view on the web, you can search for them. I found a nomogram that matched my issue (DCIS recurrence risk), and brought up the new guideline with them in October 2022 and they agreed to the 5 mg. Mayo Clinic probably has something similar. I found guides by Memorial Sloan Kettering on the web, as well.

You might ask your oncologist to re-look at your case. In 2022 they may have been following current guidelines.
The National Comprehensive Cancer Networks 2023 guidelines on breast cancer risk also should show that 5 mg is an option, but with lower efficacy.

Thank you for your information We try to comply with treatment
But often feel the need to critique prescribed treatment
So comforting to learn not alone and sharing information that others have found out and what worked for them
Sally in Ca🙏