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← Return to Methotrexate / Actemra
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Polymyalgia Rheumatica (PMR) | Last Active: Feb 2 6:53pm | Replies (40)
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When I developed antibodies to Humira it just ceased to be effective rather suddenly. I don’t recall that they tested for antibodies, but I think it’s an assumption borne of experience.
Is developing antibodies to Actrema a thing? I know some biologics don’t trigger antibody development. And if it does do you have other biologic options?
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My rheumatologist seemed to think there was a risk of me developing antibodies to Actemra. I got the impression antibody formation against all biologics was a possibility.
We were talking about alternatives to Actemra at my last visit. Kevzara was mentioned as the first option.
There was more discussion about uveitis flaring up again. Actemra isn't supposed to work for uveitis. Humira should work for uveitis but it didn't work for PMR.
The question posed by one rheumatologist to another was what to do if uveitis flares up again. I was speechless by the conversation about inflammation pathways along with up and downstream regulation of this and that. The conclusion was IL-23 blockade might work too.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538052/
The complexity of all this is truly amazing. I asked how my rhematologist knew so much. He said he had the same problem ... not with PMR but uveitis. He said when more than one autoimmune condition is involved, it is extremely difficult to optimally treat everything.
I guess that's why I'm so interested in people with multiple autoimmune problems. It took me years to grasp the idea it could be more than one thing going on.
I think PMR is still in the dark ages as far as treatment options. More prednisone like it is used for PMR might not be the best option if something else happens.