Hello, I was prescribed many drugs all at the same time and now that I have done more research they were high doses. My primary care physician was throwing everything my way...and I was getting worst and worst: Carvedilol 50MG 2 times a day, Hydrochortiozide 25 mg, Losartan 100 mg, Doxazosin 4 mg, and Hydralazine 25 mg as needed for BP that went above 160/90....and it did go above that number several times a day! If you count that's 6 to 7 pills a day---all day...I was popping pills like eating M&Ms. Then he gave up after I kept calling and referred me to a cardiologist because he could not understand why my body was not responding to the drugs. Well, the reason I was not responding is that they were all the wrong drugs! It's important to get on the computer and try to figure out what these drugs are and how they could affect your body. I Googled the fact that African Americans respond to Calcium Channel Blockers and Ace Inhibitors ... come on!!!! I have been through 3 months of hell because no one seemed to realize this. My former doctor passed away and went to a new doctor. Sad to say, I don't believe he is the doctor for me.