I have posted on different places about my experience with Evenity but in response to your question, the adverse effects I experienced from Evenity-joint/muscle pain, spasms, gradually went away after about 6 months after last injection. I went into Evenity as a healthy 66 year old, with osteoporosis, who is pretty active (skiing, mountain biking, walking, hiking) and never had any pain before Evenity. I thought I had ruined my health as I could barely move after 11 months. The pain started at about 6 months and I decided to push through. I quit after 11th month. My gains in all three sites took me out of the osteoporosis range. My spine improvement went from -3.8 to -2.1 which is great. I started Fosomax after Evenity and all negative effects started to come back. I switched to Actonel, 1x/month, and am doing fine. Mild aching and no negative effects to date. Hope this helps. I did read that with Evenity the best bone building results are achieved within the first six months. If this is true, I would have stopped after month 6 or 7.