Has anyone looked into prolotherapy for back pain? I met a physical therapist, Brenda, who had very loose ligaments in her back, had prolotherapy and it really helped her. It was done by a neurosurgeon in San Francisco, California. The doctor is now retired, however. my understanding of what prolotherapy is, is that it's an injection of a sugar solution into a joint or ligament. I know it sounds hokey, but I have an evidence that it's effective for certain kinds of pain.