@velmaforever, Stable is good! Glad the targeted therapy is working for you. Unfortunately, many of these meds come with a long list of side effects. They are keeping us alive, while presenting us with other challenges. I take a different targeted therapy (alectinib for ALK), which also has a documented side effect of weight gain. You do want to make sure the weight that you are gaining isn't water, so be sure to watch for swelling ankles or fingers. Other than that, I'm not sure I have much advice, as I've gained some weight too. I try to eat healthy most of the time and go to the gym which seems to be good for my mental health too. I'm trying to accept the weight, but it's not easy.