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Evenity Side Effects

Osteoporosis & Bone Health | Last Active: May 20 11:26am | Replies (227)
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@windyshores

@me49 I called Amgen and they said no to one injection. My doc offered to look into it. I am talking to McCormick and trying to talk to my doc this coming week. I suppose I could just refuse the second shot.

I have an appointment for Evenity second dose AND an appointment for Reclast at this point. This is the rock and a hard place we are in!

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Replies to "@me49 I called Amgen and they said no to one injection. My doc offered to look..."
mayblin | @mayblin | Jan 21 5:42pm

@windyshores i saw this comment of yours just now. I haven’t been following this forum closely lately, but it sounds like you might cut short with evenity treatment for whatever reason?

I came across this article in which the author described some phase I and phase II results of romodozumab. One of the trial has dosing 70, 140 and 210mg monthly. It appears the data of these different dosing are pooled. BUT a Japanese trial with 70, 140, 210mg showed increasing effects on bmd with increased dosage. I believe the referencing article they gave is 10.

I’m not very versed in reading scientific paper, but the above is what I can gather roughly.

If your physician is willing to consider based on Japanese trial results, you might have a chance of halving your dose. Of course there might be lots of other published paper out there regarding dosing in RCT.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809324/#bibr4-8755122520967632

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