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Comments (2,131)

I also suffered crippling knee pain while on Anastrozole. I switched to Letrozole and started taking...

https://connect.mayoclinic.org/comment/914982/

I switched to Letrozole and started

Discussion: Anastrozole: How long do side effects last once you've stopped?

Support Group: Breast Cancer

Posted: Aug 18, 2023

I have been taking once a month Boniva for osteoporosis for a few years. Post chemo...

https://connect.mayoclinic.org/comment/1045809/

chemo and radiation, and being on Letrozole

Discussion: Breast cancer patient also with osteoporosis: AI, Prolia and Reclast

Support Group: Breast Cancer

Posted: Apr 5, 2024

@vtgal is there any other possible explanation? Other health issues, other meds? That is strange, as...

https://connect.mayoclinic.org/comment/851293/

a lot of ways but I did okay with letrozole

Discussion: Decision about Letrozole

Support Group: Breast Cancer

Posted: Apr 29, 2023

Just sharing a recent article about early research proposing a potential additional positive benefit to the...

https://connect.mayoclinic.org/comment/1358461/

additional positive benefit to the AI letrozole

Discussion: Decide against aromatase inhibitors?

Support Group: Breast Cancer

Posted: Jul 28, 2025

Is there any empirical evidence linking estrogen loss from AIs to cognitive function? I have not...

https://connect.mayoclinic.org/comment/285370/

I have been faithfully taking my letrozole

Discussion: Cancer Related Brain Fog: How do you cope with it?

Support Group: Cancer: Managing Symptoms

Posted: Dec 5, 2019

Aromatase inhibitors (AIs) lower estrogen levels but work somewhat differently than Tamoxifen. They tend to be...

https://connect.mayoclinic.org/comment/1097076/

I've been on letrozole, an AI, for

Discussion: Does everyone experience bad side effects from Tamoxifen?

Support Group: Breast Cancer

Posted: Jun 30, 2024

Thank you, I’m already taking Letrozole and doing well on it. I have had some hair...

https://connect.mayoclinic.org/comment/881325/

Thank you, I’m already taking Letrozole

Discussion: My path report says invasive ductal carcinoma with apocrine features.

Support Group: Breast Cancer

Posted: Jun 19, 2023

Yes, that’s what they’re suggesting for me. Thanks for mentioning Letrozole. One thing at a time...

https://connect.mayoclinic.org/comment/1159515/

Thanks for mentioning Letrozole.

Discussion: Lobular Breast Cancer: Let's share and support each other

Support Group: Breast Cancer

Posted: Oct 19, 2024

I've decided not to take abemaciclib. Everything I know about my diagnosis in the pathology reports...

https://connect.mayoclinic.org/comment/1248563/

I will be starting letrozole this week

Discussion: Deciding whether to go on abemaciclib (brand name Verzenio)

Support Group: Breast Cancer

Posted: Mar 2, 2025

@nancyn99: Aromatase inhibitors (AIs) are prescribed medications that stop most estrogen production in the body, such...

https://connect.mayoclinic.org/comment/1200124/

estrogen production in the body, such as: Letrozole

Discussion: New breast pain 20 years post lumpectomy

Support Group: Breast Cancer

Posted: Dec 30, 2024

Gosh you come off as stoic in your post! Sorry you have gone through all that...

https://connect.mayoclinic.org/comment/1106412/

not give me a bisphosphonate during letrozole ... report all kinds of side effects on letrozole

Discussion: New onset of dull, aching pain in mid and lower spinal area

Support Group: Breast Cancer

Posted: Jul 16, 2024

Curvature comes from fractures resulting in lower bone density. What are your DEXA scores? I did...

https://connect.mayoclinic.org/comment/951117/

I did 5 years of letrozole and my docs ... maybe 10% bone density when I started letrozole

Discussion: Zometa, ONJ, when is it really necessary?

Support Group: Breast Cancer

Posted: Oct 20, 2023

How long did you take anastrozole? I have taken it for two years for mbc4. I...

https://connect.mayoclinic.org/comment/755808/

Dr wants me to try Letrozole with the ... Did you use letrozole?

Discussion: Letrozole and checking estrogen levels

Support Group: Breast Cancer

Posted: Oct 1, 2022

My advice is to try all AIs (including Fulvestrant) and Tamoxifen before you give up. I...

https://connect.mayoclinic.org/comment/1287985/

I did poorly on Exemestane and Letrozole ... Alternative dosing letrozole: https:

Discussion: Is there anyone that had estrogen positive cancer, without use of AI?

Support Group: Breast Cancer

Posted: Apr 23, 2025

@tammyp Tammy, Femara and letrozole are one and the same. I hope you can talk to...

https://connect.mayoclinic.org/comment/87583/

@tammyp Tammy, Femara and letrozole ... Arimidex) which was horrendous, then to letrozole

Discussion: Concerned about the side effects of anastrozole

Support Group: Breast Cancer

Posted: Oct 14, 2020

When do most people start side effects from Letrozole? I have a lot of angst about...

https://connect.mayoclinic.org/comment/1066593/

most people start side effects from Letrozole

Discussion: Letrozole: When will I start feeling/seeing side effects?

Support Group: Breast Cancer

Posted: May 12, 2024

My diagnosis and treatment was similar to yours in April 2023. A year ago I started...

https://connect.mayoclinic.org/comment/1140926/

I was switched to Letrozole which I’ ... I was doubtful Letrozole would be any

Discussion: Aromatase Inhibitors: How to choose and manage side effects?

Support Group: Breast Cancer

Posted: Sep 13, 2024

My wife just passed several month ago. She had HER2+ Receptor positive carcinoma which metastasized into...

https://connect.mayoclinic.org/comment/1277075/

infusions of Herceptin and daily doses of Letrozole ... She took the Letrozole for nearly eight

Discussion: Did you have and how do you manage Letrozole side effects?

Support Group: Breast Cancer

Posted: Apr 8, 2025

Yes, I have been on letrozole for 16 months. I started having foot pain a few...

https://connect.mayoclinic.org/comment/1465868/

Yes, I have been on letrozole for 16

Discussion: Anyone experience sore feet or heel pain from Letrozole?

Support Group: Breast Cancer

Posted: Dec 22, 2025

I kind of agree. While I take Letrozole every day and right now symptoms are manageable...

https://connect.mayoclinic.org/comment/1471966/

While I take Letrozole every day and

Discussion: Anyone take Anastrozole every other day?

Support Group: Breast Cancer

Posted: Jan 1 8:57am