KateInHawaii–I hope you get some relief soon. I have had Hashimoto’s for several years, and I’ve given up on endocrinologists to treat this problem. Not that there may not be a good one out there, I just haven’t found one. I am seeing an internist who, after many years on Synthroid, and the last few on Synthroid and Cytomel, I am finally on Nature-Throid, which is what I wanted all along. Some people may tell you to use Armour Thyroid, which is nearly identical, but I have heard some people have had to switch to Nature-Throid due to the lack of availability of Amour. Both of these products are considered natural and use thyroid extract from pigs. Synthroid and Cytomel are manufactured in labs. You may well do well on either, but I’d recommend having your doctor check both your free t4 and free t3, and make sure you are getting enough T3. This is important–many doctors will not prescribe T3 because Synthroid (T4) is supposed to convert to the needed amount of T3. Problem is that doesn’t happen for lot of people. So find a good doctor (google Top Doc for this condition), pay attention to your symptoms and get all the tests. Your symptoms should dissipate with a proper dosage of T3 and T4. And, yes, adrenal glands can become fatigued or stressed and this should be treated as well, despite the fact that Mayo doesn’t recognize Adrenal Fatigue (they’re dead wrong and I’ve got test results to prove it). Find a good integrative doctor who will test you for both conditions.