I am 2 years, 4 months post liver transplant. I, too, do not sleep during the night, with frequent (3-4) trips to urinate. The water consumption has not made a difference, I did not know that the tacrolimus and nocturia might be connected. It has just become a part of “transplant life”. I take 2 mg am and pm, along with celcept. Come to think of it, the waking up/not resting well has gotten worse since they have upped my tac dosage. It is a constant juggling act, moving puzzle pieces. I fully trust my Mayo, Jacksonville, team and thank the Lord and my donor daily for this “GIFT OF LIFE”!