PS On the flip side. After taking 100-150 mg of Tramadol every day for 12 years, except during pregnancy and nursing, I do feel withdrawal symptoms if I do not take Tramadol on a low pain day. I feel like I’m going to jump out of my skin almost. I hate that feeling! It makes me think that this drug definitely causes dependency, which I do not like. However, I have never had to go up on my dose once.