@kathyhg, Hi there. Welcome to our group. The warnings that come with these 'Big 3' antibiotics are scary, which is why I declined them years ago. I declined them because I feared for my liver. I was worried because I liked to drink 2 cocktails every evening. mainly because I felt so bad from the constant, violent coughing. My whole torso hurt from that. Plus, I was trying to escape other stressors in my life as well, and felt that my body was too fragile to take the meds. I was worried that the alcohol plus the meds would kill my liver. I have asked my current dr about the toxicity of those meds, he said they really aren't that hard on your body; just have to stay on top of the vision and hearing changes if any. He believes some people are being overly medicated with these drugs too, so that adds to the confusion. It is all very frustrating that there is no clear definition as to HOW & WHEN to treat this disease. I was diagnosed in 2005 with mac, and did not ever go on the big three. I am not certain that was a good choice as I have watched my lung function go steadily downward year after year. Finally, I sought treatment at Mayo Clinic in 2013 and my dr was able to slow the progression of losing lung function at the rate I was. If you saw my chart graph from my lung function test, it shows that I am almost dead. Mayo was so worried at how low it was; that they did pre-qualifying tests for a double lung transplant. Although I do not feel very ill, or act it; my dr says I am an anomaly. A real head scratcher. According to my lung function, I should not be doing so well. It is all about attitude. I just decided one day that I was not going to be sick any longer. Yes, I have crappy lungs, but I now can walk as long as I want, ride my bike as long as I want, and I live my life in happiness. There was a time when I couldn't do any of that. I cannot advise you on whether to take the Big 3 treatment or not. Treatment should be customized for each individual. You can click on my picture icon to see how Mayo treated me without the Big 3.