Results for search term "#sclerosing".

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Carlos PSC Program Abstracts Accepted for the 2019 Annual AASLD meeting

During the annual AASLD meeting that will take place in Boston, MA (November 8-12, 2019) our group has submitted five scientific abstracts, which have being accepted for presentation. This work ranges from discovery, to translation, and to clinical application. We are very excited to share with our followers this [...]

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New therapeutic trials for PSC offered at Mayo Clinic

  Clinical trials are an important aspect of our work as we try to find a medical therapy for patients suffering from Primary Sclerosing Cholangitis (PSC). To this end, we would like to inform the PSC community that Mayo Clinic in Rochester Minnesota is currently recruiting patients with [...]

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4th Annual Carlos PSC External Advisory Committee Meeting

On June 28, 2019 the Extramural Advisory Committee (EAC) of the Carlos Research Program in PSC met in Rochester, Minnesota for our annual scientific retreat. The retreat included updates on our scientific programs, clinical trials, and operational initiatives. The Annual Update of the Carlos PSC Research Program is [...]

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IBD: A Comorbidity of PSC

  The majority of patients with the PSC have Inflammatory Bowel Disease (IBD). In this presentation, Dr. Laura Raffals, Associate Professor of Medicine, Mayo Clinic College of Medicine provides a comprehensive review of the epidemiology, diagnosis, outcomes and management of IBD among PSC patients.

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Cholangiocyte Pathobiology

  In a review published in Nature Reviews Gastroenterology and Hepatology this month (see below), Jesus Banales et al., provides an excellent and comprehensive overview of cholangiocyte pathobiology as relates to the development of biliary diseases like PSC. Initially, the authors emphasize on the normal function of cholangiocytes, [...]

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PSC literature elsewhere: Ursodeoxycholic acid therapy in pediatric PSC

Recently, we have made the decision to include periodically in our PSC blog commentaries of selected clinical studies published by other groups. This tactic aims at keeping the followers of this blog informed about current efforts of the academic community at large to better understand and treat PSC. [...]

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Potential Impact of cfDNA Technologies in Disease Management

Cell free DNA (cfDNA) are degraded DNA fragments released to the blood stream during health and disease. This discovery was made more than 50 years ago. However, it was not until recently with the advent, scalability and [...]

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Genes and Environment in PSC

On May 21-23, 2019, the 15th Annual Conference of the “PSC Partners Seeking a Cure” took place in Rochester, Minnesota. More than 315 patients and family members attended the meeting. We are honored and grateful that “PSC Partners Seeking a Cure” choose Rochester and Mayo Clinic as their destination [...]

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15th annual conference for PSC patients and caregivers in Rochester, MN

We are privileged to host in Rochester, Minnesota the 15th annual conference for PSC patients and their caregivers (June 20-23, 2019). In a partnership with the PSC Partners Seeking a Cure we have created an exciting and informative program (please see the attached agenda). During this conference, we will highlight our current state of-the-art research efforts, and [...]

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Efficacy and safety of curcumin in PSC: an open label pilot study

In this month’s issue of the Scandinavian Journal of Gastroenterology John E. Eaton et al., reports on the results of a 12-week open-label pilot study to examine whether curcumin, a naturally occurring compound, could reduce the markers of cholestasis in patients with PSC. Curcumin is the principal curcuminoid of [...]

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Alterations of the bile microbiome in Primary Sclerosing Cholangitis

In a study published this month in Gut, T. Liwinski, et al., reports on the differences of the microbiome and bile acid composition seen in the bile fluid of patients with PSC compared with healthy controls. 43 patients with PSC and 22 controls were included and bile specimens were [...]

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PSC and Inflammatory Bowel Disease (IBD): Women’s Health Issues

Female patients with the PSC and inflammatory bowel disease (IBD) have unique health and disease issues to deal with. During the 15th Annual Conference of the “PSC Partners Seeking a Cure”", Dr. Alina Allen, Assistant Professor of Medicine, Mayo Clinic College of Medicine, and Dr. Laura Raffals, Associate [...]