Primary Sclerosing Cholangitis (PSC)

Welcome to the online home of the Chris M. Carlos and Catherine Nicole Jockisch Carlos Endowment for Primary Sclerosing Cholangitis (PSC). Thanks to support provided by this endowment, dedicated Mayo Clinic investigators and their teams are making strides to better understand and treat PSC patients, with the ultimate goal of developing a cure for this disease.

Follow the PSC page and stay up-to-date as we post news about advances in PSC research, clinical trials, and available resources.


Clinical Trials are an integral part of Primary Sclerosing Cholangitis (PSC) research. Currently, there are three clinical trials being organized by Mayo Clinic's PSC research team.

Ongoing Clinical Trials

A Study Evaluating the Safety and Efficacy of Curcumin in Patients with Primary Sclerosing Cholangitis

This pilot study is looking at the effects of curcumin on the changes to alkaline phosphatase in PSC patients. Curcumin is a naturally occurring anti-oxidant with anti-inflammatory properties.

A Prospective, Randomized, Multi-Centered, Placebo-Controlled Clinical Trial of Oral Vancomycin in Adults with Primary Sclerosing Cholangitis

This phase II, randomized, placebo-controlled clinical trial is designed to examine the safety, tolerability and efficacy of daily dosing (over an 18-month period) with oral vancomycin, using a stepped-up dosing strategy with three increasing doses, on the clinical course, and the progression of PSC, and to compare the treated patients with those on placebo.

Multi-omics of Primary Sclerosing Cholangitis

This translational study seeks to generate the first, multi-omics and comprehensive clinical data resource for PSC. The study aims to define the bigger-picture cellular networks and gene-environment interactions driving PSC by integrating several layers of -omics data. In so doing, we will identify molecular disease signatures, including environmental toxins, metabolism-related chemicals and gut bacteria, unique to PSC patients.

Clinical Trials and PSC

In the following video, Dr. John E. Eaton details the importance of clinical trials in PSC research.

In this video, Dr. Eaton describes the challenges in developing clinical trials for PSC research.

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