Primary Sclerosing Cholangitis (PSC)

Welcome to the online home of the Chris M. Carlos and Catherine Nicole Jockisch Carlos Endowment for Primary Sclerosing Cholangitis (PSC). Thanks to support provided by this endowment, dedicated Mayo Clinic investigators and their teams are making strides to better understand and treat PSC patients, with the ultimate goal of developing a cure for this disease.

Follow the PSC page and stay up-to-date as we post news about advances in PSC research, clinical trials, and available resources.

Aug 26, 2019

New therapeutic trials for PSC offered at Mayo Clinic

By Ethan McConkey, Moderator, @ethanmcconkey



Clinical trials are an important aspect of our work as we try to find a medical therapy for patients suffering from Primary Sclerosing Cholangitis (PSC). To this end, we would like to inform the PSC community that Mayo Clinic in Rochester Minnesota is currently recruiting patients with PSC for two clinical trials:

1. Investigation of oral vidofludimus as a treatment for PSC: an open label clinical trial.

For study details including inclusion and exclusion criteria please see this link.

2. Phase 3, randomized, double blind, placebo-controlled study evaluating oral GS-9674 (Cilofexor) in non-cirrhotic subjects with PSC

For study details including inclusion and exclusion criteria please see this link.

Join others discussing PSC


I have aged and transplanted out of this study. However, as a PSCer with a successful liver and kidney transplant, I am happy everytime that I read about the research that is happening related to PSC. I have hope that one day, others will not have to suffer with this ugly disease.

I am thankful for my PCP who first noticed my elevated liver function labs, for my GI who took marvelous care of me, for my original transplant team who knew to send me to Mayo, and for everyone at Mayo who had a role in my treatment and care.
@ethanmcconkey, Thank you for keeping me and all PSCers updated with what is happening.

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