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Mon, Jul 2, 2018 12:45pm

Researching DNA test for liver cancer

By Tony Hart, Champion Specialist, @TonyHart87

Researcher

Liver cancer is the second most common cause of cancer death worldwide. Researchers from Mayo Clinic and Exact Sciences Corporation have developed a simple blood test using abnormal DNA markers that are known to exist in liver cancer tissues. A phase II study for this test has been completed. The next step is to validate the markers in blood testing on larger patient cohorts.

“We were most excited that our DNA markers were able to detect more than 90 percent of patients with curable stage tumors,” says John Kisiel, M.D. “This is the main reason why we think a DNA test will make difference, compared to currently available tests.”

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About Mayo Clinic Cancer Center

As a leading institution funded by the National Cancer Institute, Mayo Clinic Cancer Center conducts basic, clinical and population science research, translating discoveries into improved methods for prevention, diagnosis, prognosis and therapy. Learn more about clinical trials for cancer.

This is amazing and great news – my liver is ok but I get it checked every 6 month

Where can I get this blood test? Is it available at most health facilities, or only those connected with Mayo Health Systems? I have a grandfather and brother who both died of liver cancer, so I and other family members would of course be most interested in this blood test.

@cherriann

Where can I get this blood test? Is it available at most health facilities, or only those connected with Mayo Health Systems? I have a grandfather and brother who both died of liver cancer, so I and other family members would of course be most interested in this blood test.

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The test is still in development. Research is being conducted at Mayo Clinic but a patient would only be eligible if they have a liver cirrhosis or a known liver cancer diagnosis.

Very exciting research. I had a grandfather pass away form liver cancer. I also worry about my one Son who lacerated his liver as a child and another son who has high liver enzymes. This test maybe beneficial to them in the future. If anything for piece of mind.

I took 23andme. It does all cancers well because there are ones there that are new to me. I have Lynch Syndrome so lots of colon cancer so I copied the gastric one. The liver one was too long. rs2811712(A;A)
Normal (higher) risk of physical impairment with age. This causes physical problems for older people, and Cerebral Small Vessel Disease in the brain.
rs2811712 is a SNP associated with physical function in older individuals, and thus indirectly associated with longevity. In a study ultimately totaling over 3,300 elderly Caucasian individuals, the less common rs2811712(G) allele was associated with reduced physical impairment. Overall, severely limited physical function was present in 15.0% of the more common rs2811712(A;A) homozygotes, versus 7.0% of the rs2811712(G;G) homozygotes, yielding a per risk allele odds ratio of 1.48 (CI: 1.17-1.88, p=0.001). Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. Consortium analysis of 7 candidate SNPs for ovarian cancer. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk….

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