Gastroenterology & GI Surgery

Welcome to the Mayo Clinic Gastroenterology & GI Surgery Page! With one of the largest group of digestive disease specialists in the world, Mayo Clinic has been recognized as the nation's best Gastroenterology & GI Surgery hospital by U.S. News & World Report. Follow the page to learn about clinical trials and up-to-date research, and find resources for all your gastroenterology needs. Our goal is to connect you to others, and become informed decision makers; so post a comment, share your story, own your health.

Jul 1, 2017

When Your Diagnoses of Celiac Disease is in Question

By Kanaaz Pereira, Connect Moderator, @kanaazpereira

Blood tests for celiac disease are usually accurate, but what does it mean when there is a discrepancy between biopsies suggesting celiac disease, but blood tests are negative? In response to a question from a Mayo Clinic Connect member, Dr. Joseph Murray, M.D., explains that there may be other conditions that can cause changes in the intestinal biopsy that are characteristic of celiac disease. Tropical sprue, certain medications, or infections can cause damage to the intestinal wall.

Other reasons could be IgA deficiency; people with this disorder have absent levels of a blood protein called immunoglobulin A (IgA), which protects against infections of the mucous membranes lining the mouth, airways and digestive tract. Why is it important to investigate and identify intestinal damage when test discrepancies occur? They may have alternate causes and subsequently alternate treatment, Dr. Murray emphasizes.

For more information about celiac disease, visit disease

Dr. Murray, M.D., is a gastroenterologist and celiac disease expert at Mayo Clinic.

Please login or register to post a reply.

Invite Others

Send an email to invite people you know to join the Gastroenterology & GI Surgery page.

We'll include this text in the user's invitation.