Perianal fistulas are a common, disabling complication of Crohn’s disease. Symptoms include severe pain, fecal incontinence, drainage of pus, and reduced quality of life. Despite significant advances in the treatment of inflammatory bowel disease (IBD), the treatment of perianal fistulas remains a challenge.
Anti-tumour necrosis factor (anti-TNF) biologic therapies, infliximab and adalimumab have been shown to be effective treatments in healing fistulas in adult patients with Crohn’s disease. In this video, Dr. Michael Stephens discusses two studies – IMAgINE 1 & IMAgINE 2 – which concluded that adalimumab treatment led to improvement and fistula closure within 12 weeks in children and adolescents with Crohn’s disease.
Dr. Stephens also talks about new approaches and techniques being studied by researchers at Mayo Clinic, which hold promise for a better outcome in treatment of perianal fistulas.
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