Genetic predisposition plays a key role in celiac disease (CD), and that could mean as many as a third of the population are genetically at risk! The great majority however, never get celiac disease. Dr. Joseph Murray explains the results of a recent study that delves deeper into finding the various genomic factors responsible for CD predisposition. The published study can be found in the journal PLOS One.
According to the study: "Although the HLA genotypes are necessary for celiac disease, they are common and insufficient to cause disease, and each individual celiac patient will have a genetic etiology that includes non-HLA disease alleles." Considerable progress has been made in identifying these genes, but there are many gaps that need to be filled to fully understand the genetic architecture of celiac disease.
Read the full study online here.
For more information about celiac disease, visit mayoclinic.org/celiac disease.
Dr. Murray is a gastroenterologist and celiac disease expert at Mayo Clinic.