Eosinophilic Esophagitis

Welcome to the Mayo Clinic Eosinophilic Esophagitis page. EoE is a relatively new diagnosis and is most commonly experienced via food sticking with swallowing in adults. This is a result of an allergic response in the esophagus. We are a leading center for research and clinical care.

Follow this page to read up on news in our EoE clinic, including patient experiences, physician insight, clinical trials and up-to-date research and other useful information about EoE. Post a comment, share your thoughts and be connected.



Available Clinical Trials

ResearchTalkingOur team of experts are diving into figuring out eosinophilic esophagitis, and that comes with asking a lot of questions. There are many research studies going on that are available for our patients to participate in.

Check this tab often as we are continually adding research opportunities!


A pilot trial of dietary therapy directed by the esophageal sponge in the management of eosinophilic esophagitis

  • Patients who have responded to eliminating the six foods as part of their clinical care may participate in the cytosponge trial in lieu of having endoscopies during food reintroduction. During a 10 minute office visit, participants will swallow the Cytosponge, a gelatin capsule with a string attached, for 5 minutes. The sponge is then pulled back up, sampling the entire esophagus. Samples are sent to the lab and are giving reliable results on how to direct food reintroduction. Office visits and the cytosponges are covered by the study.


A phase 3, randomized, 3-part study to investigate the efficacy and safety of Dupilumab in adult and adolescent patients with eosinophilic esophagitis

  • Participants who have not responded to high dose PPI trial via proven endoscopy may participate in this randomized controlled drug study. Patients may receive either Dupilumab injection or placebo injection, and will return for bi-weekly office visits. Study procedures, medication, and travel reimbursements covered by the study as well as participant remuneration.


Food antigen staining in esophageal mucosa in patients with eosinophilic esophagitis

  • Participants will be asked to fast from gluten and dairy for 12 hours, 24 hours, or 3 days. During standard of care endoscopy, an additional two biopsies (pinches of tissues) will be taken from the esophagus. Researchers are looking to see if gluten and/or dairy proteins are still present in the esophageal tissue despite specific timeframe avoidance. Study biopsies will not be charged to the patient, and remuneration is offered.

Is EPO staining on esophageal sponge samples a simple reliable method of assessing esophageal eosinophilia?

  • Participants will swallow the Cytosponge during a 10 minute office visit 2 hours prior to their EGD. The Cytosponge is a gelatin capsule attached to a string, which expands into a sponge when dissolved in the stomach in about 5 minutes. The sponge is then pulled back up, taking a sampling of the entire esophagus. Researchers are developing a bedside stain to indicate high or low counts of eosinophils on the sponge. Office visit covered by the study, as well as remuneration.

Assessment of fibrotic and inflammatory components by MRI in strictures associated with eosinophilic esophagitis before and after treatment

  • Participants undergo two MRI’s of the esophagus, one before starting a treatment plan and one after. Researchers are looking to see if fibrosis and stricturing are present via MRI scan to help predict if certain treatments could be better suited for some patients long-term. Study procedures are covered and remuneration offered.

We have many research studies going on at all times regarding Eosinophilic Esophagitis. Search more trials throughout Mayo Clinic, or contact our study coordinators at eosinophilic@mayo.edu.

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